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Collamer®, Toric, and Silicone IOL Models - Intraocular Lens Cataract Solutions

STAAR® Surgical Company develops, manufactures, and distributes world-wide an array of foldable intraocular lenses ( IOLs). The company offers various IOLs that are used in cataract surgery, each with its own set of advantages.

In order to satisfy various cataract surgical correction needs, from basic cataract removal to astigmatic surgical correction, STAAR Surgical Company has designed distinct IOL models. The Afinity™ 3-Piece Collamer Aspheric IOL and the nanoFLEX™ Collamer Aspheric Single-Piece IOL are highly biocompatible, providing sharp image quality, and increased functional vision. The STAAR Toric™ IOL is designed for cataract patients with astigmatism between 1.5D and 3.5D.

• Collamer IOLs


• Single-Piece Aspheric (nanoFLEX™ IOL):
• CC4204A [NTIOL Approved]


• 3-Piece Aspheric (Afinity™ IOL):
• CQ2015A [NTIOL Approved]

• Silicone IOLs
• 3-Piece (STAAR Elastimide® IOL):
• AQ2003V
• AQ2010V
• AQ5010V (Low Diopter)
• AQ2017V (Model Discontinued)
• AQ1016V (Model Discontinued)



• 3-Piece Aspheric (STAAR Elastimide® IOL):
• AQ2015A [NTIOL Approved]
  
  
• Single Piece (STAAR Elastic Lens®):
• AA4204VF
• AA4204VL
• AA4207VF (Model Discontinued)
  
  
• STAAR Toric Silicone Single Piece IOL [CMS Approved]:
• AA4203TF
• AA4203TL
• Toric Online Calculator - www.STAARToric.com

• Preloaded IOL (Available Internationally Only)
• Canon-STAAR Preloaded IOL KS-3Ai

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Afinity™ and nanoFLEX™ Collamer Aspheric IOLs

Created for the treatment of cataracts through surgical correction, the Afinity™ and nanoFLEX™ Collamer Aspheric IOLs from STAAR Surgical Company are comprised of the unique, biocompatible Collamer material.

The Collamer Advantage

Exclusive to STAAR Surgical Company, Collamer is a unique lens material that is composed of collagen, a UV-absorbing chromophore, and a poly-HEMA based copolymer .¹ The Afinity™ and nanoFLEX™ Collamer Aspheric IOLs produce excellent optical performance and achieves significant biocompatibility.

Exceptional Quality of Vision

• Collamer lenses provide exceptional quality of vision. ^{2, 3}
• Compared to other lens materials (including acrylic and PMMA), Collamer has less internal reflectance, reducing or eliminating the occurrence of glare and halos. ⁴
• Collamer induces fewer higher order aberrations than other lens materials. ²

Collamer IOL

• Index of refraction: 1.44
• No visible glare, halos or ghosting

Silicone IOL

• Index of refraction: 1.41
• No visible glare, halos or ghosting

Acrylic IOL

• Index of refraction: 1.55
• Visible glare, halos and ghosting

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Significant Biocompatibility

• Collamer possesses inherent biocompatibility. ⁴
• The lens material attracts fibronectin. A monolayer around the Collamer IOL shields it from the body's immune system. ^{4, 5}
• The collagen in Collamer produces a slight negative ionic charge, repelling protein attachment on the lens surface.⁴

Acrylic Lens : (Magnified 1,000 times) After one-minute of exposure to protein mixture, note the dense existing protein deposition.

Collamer Lens : (Magnified 1,000 times) After one minute of exposure to the same protein mixture, note the near absence of protein on the Collamer IOL.

Acrylic IOL vs. Collamer IOL

Excellent for Patients with Specific Health Issues

• Collamer lenses do not encounter the same problems that other lens materials do in patients with specific health conditions including diabetes, chronic uveitis, iritis, and other inflammatory conditions of the anterior chamber. ⁶
• Collamer is appropriate for patients precluded from other lens use due to specific health conditions impacting the eye. ⁶
• The unique properties of Collamer do not induce long term "flare," decreases inflammation, and prevents cellular attraction. ^{6, 7}

Patient Satisfaction

• Collamer lenses deliver superior outcomes and satisfaction among a wide range of cataract surgery patients. ^{1, 6}

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nanoFLEX™ Collamer Aspheric Single-Piece IOL
Model CC4204A

NTIOL Ruling Fact Sheet

Optic Material: Collagen-Copolymer (Collamer) - highly biocompatible material
Optic Specifications: 6.0 mm Biconvex Aspheric
Length: 10.8mm
Haptics: Collamer Single-Piece (Plate) 0.9 mm Fenestration
Diopter Range/Increments: 10.5 - 30.5
Suggested A-Constant/ACD: 119.0, 5.55 mm

nanoFLEX™ is designed to provide sharp image quality and increased functional vision

• nanoFLEX™ is designed to have a negative spherical aberration of -0.019 microns. This compensates for a mild positive spherical aberration of the cornea and improves contrast sensitivity without compromising depth-of-field ⁹

nanoFLEX™ reduces spherical aberration and improves contrast sensitivity

...without compromising depth of field⁹

The nanoFLEX™ aspheric optic is designed to compensate for decentration and tilt without loss of visual acuity¹⁰

• The optics were designed using a curved retina model that most closely simulates in situ conditions
• Most competitor aspheric optics have been designed using a flat retina model and do not compensate for decentration and tilt

nanoFLEX™ is made from the unique, highly advanced hydrophilic Collamer® material

• Collamer® has a water content of 40% which is over 50% higher than any other FDA approved hydrophilic IOL material. This high water content gives nanoFLEX™ some of its key functional attributes⁴
  • Anti-reflective properties
  • Softness and flexibility

Collamer has a built in Anti-Reflective interface due to the surface having a higher water concentration than the bulk of the lens. 40% of the lens is comprised of water¹³

Hydrophilic Collamer is free from glistenings, a complication commonly associated with some hydrophobic acrylic IOL materials^15,16

• Some hydrophobic acrylic materials contain microscopic openings referred to as microvacuoles that over time can fill with water, creating glistenings that may reduce contrast sensitivity^15,16
• The unique hydrophilic Collamer® material is microvacuole free

nanoFLEX™ is extremely hydrophilic with a built-in anti-Reflective layer¹³

• The risk of dysphotopsia due to internal reflections increases as light passes through materials with different refractive indexes (RI)^16,17
• The difference in refractive index is most critical at the interface or transition between materials
• The hydrophilic nature of Collamer� gives nanoFLEX™ an ultra-high water content layer on its surface, minimizing the difference in refractive index at the interface with the aqueous and the vitreous humor. This significantly reduces the refractive index of the lens surface¹³

nanoFLEX™ induces 6 times fewer visually disturbing light reflections than a hydrophobic acrylic lens

nanoFLEX™ Collamer® Aspheric IOL generates low internal reflectance to improve vision which is nearly identical to that of the human crystalline lens.^2,4

Light reflections are due to the differences in refractive index.

nanoFLEX™ is soft and flexible which can be inserted through a 2.2 mm incision with the nanoPOINT™ injector system

• Precise lens positioning is achieved via a highly accurate plunger style delivery mechanism
• The nanoPOINT™ cartridge can be inserted through a "true" 2.2mm incision allowing nanoFLEX™ to be implanted directly into the capsular bag
• Other competitor insertion systems require "wound-assisted" injection techniques to achieve this micro-incision size

nanoPOINT™ Injector System is easy to load and is easy to use. helps optimize safe surgical outcomes and improve recovery rates

• The smaller 2.2 mm micro incision can help reduce surgically induced astigmatism, improve chamber maintenance during the surgical procedure and reduce healing time for the patient

nanoFLEX™ Collamer is highly biocompatible containing collagen that attracts fibronectin. This fibronectin quickly forms a protective layer on the surface of the lens

• This protective layer is highly biocompatible and makes the lens "invisible" to the body preventing the lens from being identified as a foreign object^5,18
• lens surface a slight negative charge that helps to inhibit cell adhesion and deposition of other proteins⁹

The fibronectin layer that forms on Collamer® removes the risk of calcification, a complication associated with hydrophobic acrylic materials^19,20,21

• Studies have shown that all hydrophilic acrylic materials have the potential to attract calcium deposits
• The Collamer® material being invisible to the body is protected from the risk of calcification

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Afinity 3-Piece Collamer Aspheric IOL
Model CQ2015A

NTIOL Ruling Fact Sheet

Optic Material: Collagen-Copolymer (Collamer) - highly biocompatible material
Optic Specifications: 6.0 mm Equiconvex Aspheric
Length: 13.0 mm
Haptics: Polyimide Modified "C" Loop 5° Angulation
Diopter Range/Increments: 10.5 - 30.5
Suggested A-Constant/ACD: 118.4, 5.20 mm

Designed to perform optimally even in a decentered or tilted position


• IOL displacement is a common occurrence: 33% of patients experience postoperative decentering and/or tilt¹⁰
• When decentering of lenses occurs, resolution of the lens is decreased resulting in a loss of visual acuity
• The Afinity™ Collamer® Aspheric IOL is optimized to accommodate decentering and tilt without loss of visual acuity

Modulation Transfer Function (MTF) analysis of different lenses demonstrates exceptional performance with the Afinity™ Collamer® Aspheric IOL in on-axis, decentered, and tilted positions⁹

Greater MTF=Higher quality of vision

Provides sharp image quality and increased functional vision by design


• Modeled on a curved retina, the Afinity™ Collamer® Aspheric IOL is optimized to simulate in situ conditions

Afinity™ Aspheric IOL Design

• Small amount of negative spherical aberration compensates for the positive aberration of the average cornea and the curved retina
• The total eye (cornea+IOL+curved retina) carries a residual positive spherical aberration

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Silicone IOL

A single piece foldable silicone IOL was the first intraocular lens developed and produced by STAAR Surgical Company. Through ongoing research and development, the company offers several models of both the single piece STAAR Elastic Lens, the 3-Piece STAAR Elastimide Lens, and the STAAR Silicone Elastimide Aspheric Lens.

Elastimide Silicone Aspheric IOL
Model AQ2015A

NTIOL Ruling Fact Sheet

Optic Material: Silicone, covalently-bonded UV absorbing (10 percent transmission at 395nm). Material is completely biologically and chemically inert.
Optic Specifications: 6.0 mm Posterior Aspheric
Length: 13.0mm
Haptics: Polyimide, Modified “C” Loop 0° Angulation.
Diopter Range/Increments: 10.5 - 30.5
Suggested A-Constant/ACD: 118.8, 5.44 mm

Designed to perform beyond the ordinary.

• Elastimide® Aspheric IOL induces fewer spherical aberrations than a traditional lens

Provides sharp image quality and increased functional vision by design

• Modeled on a curved retina, the Elastimide® Aspheric IOL is optimized to simulate in situ conditions

• Small amount of negative spherical aberration compensates for the positive aberration of the average cornea and the curved retina
  • The total eye (cornea+IOL+curved retina) carries a residual positive spherical aberration

STAAR Elastimide Lens
Model AQ2003V

The STAAR Elastimide lens, model AQ2003V, combines foldable IOL technology with a traditional cataract IOL design. The AQ2003V contains a cast-molded, silicone optic with modified “C” loop polyimide haptics with no angulation. These loops offer flexibility comparable to polypropylene and PMMA haptics, with greater tensile strength, and superior “shape memory.”

Optic Material: Silicone, covalently-bonded UV absorbing (10 percent transmission at 395nm). Material is completely biologically and chemically inert.
Optic Specifications: 6.3 mm, Biconvex, 1.1 Ratio
Length: 12.5 mm
Haptics: Polyimide, Modified "C" Loop 0� Angulation.
Diopter Range/Increments: 9.5 - 30.5 (0.5 increments)
Suggested A-Constant/ACD: 118.5, 5.26
Injectors: MSI-TM, MSI-PM
Cartridges: AQ Cartridge
Available: United States

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STAAR Elastimide Lens
Model AQ2010V

The STAAR Elastimide lens, model AQ2010V, utilizes a combination of foldable IOL technology and conventional design. This lens contains a cast-molded, silicone optic with modified “C” loop Polyimide haptics with 10° angulation. These loops offer flexibility comparable to polypropylene and PMMA haptics, with greater tensile strength, and superior “shape memory.”

Optic Material: Silicone, covalently-bonded UV absorbing (10 percent transmission at 395nm). Material is completely biologically and chemically inert.
Optic Specifications: 6.3 mm, Biconvex, 1.1 Ratio
Length: 13.5 mm
Haptics: Polyimide, Modified "C" Loop 10� Angulation.
Diopter Range: +5.0 to +9.0 in full diopter increments
+9.5 to +30.5 in half diopter increments
Suggested A-Constant/ACD: 119.0, 5.55
Injectors: MSI-TM, MSI-PM
Cartridges: AQ Cartridge
Available: United States

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STAAR Elastimide Lens
Model AQ5010V - Low Diopter

The STAAR Elastimide lens, model AQ5010V, is a STAAR Surgical Company foldable IOL. This low diopter lens contains a cast-molded, silicone optic with modified "C" loop Polyimide haptics with 10° angulation. These loops offer flexibility comparable to polypropylene and PMMA haptics, with greater tensile strength, and superior "shape memory."

Optic Material: Silicone, covalently-bonded UV absorbing (10 percent transmission at 395nm). Material is completely biologically and chemically inert.
Optic Specifications: 6.3 mm, Convex/ Plano - (+ 1 to +4D)
Plano/Plano - (0D)
Plano/Concave - (-1 to -4D)
Overall Length: 14.0 mm
Haptics: Polyimide, Modified "C" Loop 10� Angulation.
Diopter Range/Increments: -4.0 - + 4.0 (in full diopter increments)
Suggested A-Constant/ACD: 119.0, 5.55 mm
Injectors: MSI-TM, MSI-PM
Cartridges: AQ Cartridge
Available: United States

The optic design changes from convex/plano to plano/concave as you move down the diopter range. The posterior side of the optic in lenses -1.0 through -4.0 is concave.

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STAAR Elastimide Lens
Model AQ2017V (Discontinued)

A foldable IOL, the STAAR Elastimide lens, model AQ2017V, contains a cast-molded, silicone optic with modified “C” loop Polyimide haptics with 10° angulation. These loops offer flexibility comparable to polypropylene and PMMA haptics, with greater tensile strength, and superior "shape memory."

Please note that model AQ2017V of the STAAR Elastimide lens has been discontinued.

Optic Material: Silicone, covalently-bonded UV absorbing (10 percent transmission at 395nm). Material is completely biologically and chemically inert.
Optic Specifications: 5.5 mm, Biconvex, 1.1 Ratio
Length: 12.5 mm
Haptics: Polyimide, Modified "C" Loop 10� Angulation.
Diopter Range: 9.5 -30.5 (0.5 increments)
Suggested A-Constant/ACD: 119.0, 5.55
Injectors: MSI-TR, MSI-PR
Cartridges: AQ Cartridge
Available: United States

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STAAR Elastimide Lens
Model AQ1016V (Discontinued)

The STAAR Elastimide lens, model AQ1016V, is a foldable IOL. The IOL contains a cast-molded, silicone optic with modified “J” loop Polyimide haptics with 10° angulation. These loops offer flexibility comparable to polypropylene and PMMA haptics, with greater tensile strength, and superior "shape memory."

Please note that model AQ1016V of the STAAR Elastimide lens has been discontinued.

Optic Material: Silicone, covalently-bonded UV absorbing (10 percent transmission at 395nm). Material is completely biologically and chemically inert.
Optic Specifications: 6.3 mm, Biconvex, 1:1 Ratio
Overall Length: 13.5 mm
Haptics: Polyimide, Modified "J" Loop 10� Angulation.
Diopter Range/Increments: 9.5 - 30.5 (0.5 increments)
Suggested A-Constant/ACD: 119.0, 5.55 mm
Injectors: MSI-TM, MSI-PM
Cartridges: AQ Cartridge
Available: United States (This model is not available outside of the U.S. market.)

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STAAR Elastic Lens
Model AA4204VF

The STAAR Elastic Lens, model AA4204VF, is a single piece silicone IOL that is placed completely in the capsular bag. The lens has large fenestrations to enhance postoperative fixation. This allows fibrous epithelial cells to migrate through the lens holes and assures optic centration and long-term stability.

Optic Material: Silicone, covalently-bonded UV absorbing (10 percent transmission at 395nm). Material is completely biologically and chemically inert.
Optic Specifications: 6.0 mm, Biconvex, 1:1 Ratio
Length: 10.8 mm
Haptics: Silicone Single Piece, 1.15mm Diameter Fenestration.
Diopter Range: 21.5 - 30.5 (0.5 increments)
Suggested A-Constant/ACD: 118.5, 5.26
Injectors: MSI-TR, MSI-PR
Cartridges: MTC-60c
Available: United States

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STAAR Elastic Lens
Model AA4204VL

A single piece silicone IOL, the STAAR Elastic Lens, model AA4204VL, can be placed completely in the capsular bag. The IOL has large fenestrations to enhance postoperative fixation. This allows fibrous epithelial cells to migrate through the lens holes and assures optic centration and long-term stability.

Optic Material: Silicone, covalently-bonded UV absorbing (10 percent transmission at 395nm). Material is completely biologically and chemically inert.
Optic Specifications: 6.0 mm, Biconvex, 1:1 Ratio
Length: 11.2 mm
Haptics: Silicone Single Piece, 1.15mm Diameter Fenestration.
Diopter Range: 9.5 - 21.0 (0.5 increments)
Suggested A-Constant/ACD: 118.5, 5.26
Injectors: MSI-TR, MSI-PR
Cartridges: MTC-60c
Available: United States

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STAAR Elastic Lens
Model AA4207VF (Discontinued)

The STAAR Elastic Lens, model AA4207VF, is a single piece silicone IOL. The lens can be placed completely in the capsular bag. Since the cataract IOL has large fenestrations to enhance postoperative fixation, fibrous epithelial cells are able to migrate through the lens holes and assures optic centration and long-term stability.

Please note that model AA4207VF of the STAAR Elastic Lens has been discontinued.

Optic Material: Silicone, covalently-bonded UV absorbing (10% transmission at 395nm). Material is completely biologically and chemically inert.
Optic Specifications: 5.5 mm, Biconvex, 1:1 Ratio
Length: 10.8 mm
Haptics: Silicone Single Piece, 1.15mm Diameter Fenestration.
Diopter Range: 9.5 - 30.5 (0.5 increments)
Suggested A-Constant/ACD: 118.5, 5.26
Injectors: MSI-TR, MSI-PR
Cartridges: SFC-45
Available: United States

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STAAR Toric Silicone Single Piece IOL

CMS Toric Ruling Fact Sheet

The optimal balance of stability and flexibility: Predictable visual outcomes, stable design, and a price that provides you maximum flexibility in profit margins and patient conversion

Lens Stability That Gives Exceptional Visual Acuity

Design Improvements That Reinforce Rotational Stability

• Longer length 11.2 mm to prevent IOL rotation for larger myopic eyes
• Frosted haptics and larger fenestrations designed to promote greater bioadhesion for capsular bag stability

Lens Stability That Requires Minimal Repositioning

Toric Repositiong Rates^2,3,4

Optimizing Your Outcomes

Surgeons have reported posterior positioning of the toric optic reduces the cylinder power of the lens allowing you to better optimize your outcomes⁵

Surgical Pearls For Improving Outcomes

• Create a 5.5mm capsulorhexis
• Remove all viscoelastic from behind lens
• Minimize BSS inflation of the anterior segment; the eye should be left on the soft side to prevent IOL movement

Priced To Give You Maximum Flexibility

The STAAR Toric puts you in the driver's seat, giving your practice the greatest flexibility for pricing and the best profit margins. There are two ways to position your pricing:

• Profit from Cost Saving
  Maintain current pricing to the patient and profit from the cost difference of the STAAR Toric IOL.
• Profit from Higher Patient Conversion
  Offer a lower price to the patient that promotes an increase in patient toric conversation rate and increases your profits

Either way, the STAAR Toric will make your practice more profitable than using the AcrySof® Toric.

Contact your STAAR representative today to discuss which position will offer the most profitability for your practice.

The New and Improved STAAR Toric Calculator Available at STAARToric.com

• Easy and efficient data entry
• A surgical worksheet that includes preoperative data and a list of suggested powers

• A clearly labeled illustration of the exact placement of the STAAR Toric IOL

Position Toric IOL to Steep Corneal Meridian

Cylinder Power Selected According to Corneal Astigmatism Nomogram as Follows:

Nomogram assumes astigmatically neutral surgery.
¹With the Rule, steep corneal meridian between 46 to 134; Against the Rule, steep corneal meridian between 0 to 45 and 135 to 180.
²Approximate value of the equivalent IOL cylinder power at the cornea.
³Combine with Astigmatic Keratotomy or Limbal Relaxing Incisions.

References
1. Data on file, STAAR Surgical.
2. David Chang, MD. Comparing the STAAR and AcrySof Toric IOLs. Cataract & Refractive Surgery Today. May 2007.
3. David Chang, MD. Early Rotational Stability of the Longer Staar Toric Intraocular Lens - Fifty Consecutive Cases. Journal of Cataract and Refractive Surgery. May 2003.
4. David Chang, MD. Repositioning Technique and Rate for Toric Intraocular Lenses. Journal of Cataract and Refractive Surgery. July 2009.
5. Farrell "Toby" Tyson, MD, FACS. Success with the Staar Toric IOL Presentation. STAAR Surgical Booth-AAO Chicago. Oct 2010.

Previze® is a registered trademark of Previze.
AcrySof® is a registered trademark of Alcon.

STAAR Elastic Toric Lens
Model AA4203TF

Model AA4203TF is a single piece toric silicone IOL placed completely in the capsular bag. The lens is designed to correct 1.4 to 2.3D of astigmatism during cataract surgical correction. The lens has large fenestrations to enhance postoperative fixation. This allows fibrous epithelial cells to migrate through the lens holes and assures optic centration and long-term stability.

Optic Material: Silicone, covalently-bonded UV absorbing (10 percent transmission at 395nm). Material is completely biologically and chemically inert.
Optic Specifications: 6.0 mm, Biconvex, 1:1 Ratio
Length: 10.8 mm
Haptics: Silicone Single Piece, 1.15mm Diameter Fenestration.
Diopter Range/Increments: 24.0- 28.5 (0.5 increments)
Cylinders: 2.0 and 3.5
Suggested A-Constant/ACD: 118.5, 5.26
Injectors: MSI-TR, MSI-PR
Cartridges: MTC-60c
Available: United States

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STAAR Elastic Toric Lens
Model AA4203TL

Used for lens replacement during surgical vision correction of an astigmatic cataract patient, model AA4203TL is a single piece toric silicone IOL placed completely in the capsular bag. The cataract IOL is designed to correct 1.4 to 2.3D of astigmatism. The AA4203TL lens has large fenestrations to enhance postoperative fixation. This allows fibrous epithelial cells to migrate through the lens holes and assures optic centration and long-term stability.

Optic Material: Silicone, covalently-bonded UV absorbing (10 percent transmission at 395nm). Material is completely biologically and chemically inert.
Optic Specifications: 6.0 mm, Biconvex, with 2.0 or 3.5D Cylinder
Length: 11.2 mm
Haptics: Silicone Single Piece, 1.15mm Diameter Fenestration.
Diopter Range/Increments: 9.5 - 23.5 (0.5 increments)
Cylinders: 2.0 and 3.5
Suggested A-Constant/ACD: 118.5, 5.26
Injectors: MSI-TR, MSI-PR
Cartridges: MTC-60c
Available: United States

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Preloaded IOL

The preloaded IOL delivery systems are sterilized intraocular lens injection systems with 3-piece silicone IOLs preloaded. The preloaded IOLs are currently not available in the United States.

Canon-STAAR Preloaded IOL
Model KS-3Ai

The KS-3Ai Preloaded IOL is the latest development in the Preloaded IOL series from Canon-STAAR, featuring an aspheric optic. The design provides an aspheric optic and the same 6.0mm optic and a squared edge as the KS-3. The injector offers simplicity, safety and reliability. The lens is preloaded and ready to use, the delivery is consistent and controlled and offers a sterile pathway directly to the eye. The disposable injector can be used with one or two hand technique, featuring a push or screw technology in one system.

Optic Material: Silicone
Optic Specifications: 6.0 mm, square edge, aspheric
Length: 12.5 mm
Haptic Angle: 10°
Sterilization: Ethylene Oxide Gas
Suggested A-Constant: 119.5
Diopter Range : +12.5D - + 28.5D (0.5D increments)
Incision Size: 3.0mm
Available: Internationally (This model is currently not available in the United States.)

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Contact STAAR Surgical Company

With the extent of STAAR Surgical Company's intraocular lens product lines, you may have additional questions about its toric, silicone, and Collamer IOLs. Please contact STAAR Surgical Company today for more information.

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Bibliography

1. Fine IH, MD. Aiming for a new level of biocompatibility. Ophthalmology Management, 2000;5:5 (suppl).

2. Martin RG, Sanders, DR. Higher order aberrations following implantation of four foldable lens designs. ASCRS 2003.

3. Sarver E, Vukich J. Optical Quality of the ICL. ASCRS 2002.

4. Ossipov, A. Comparison of internal reflectance patterns of Collamer, acrylic and silicone. 1997. Data on file at STAAR Surgical Company.

5. Engvall E, Ruoslahti E. Binding of soluble form of fibroblast surface protein, fibronectin, to collagen. Internal Journal of Cancer. 1977;20(1): 1-5.

6. Davis E.A. Study of post-cataract surgery inflammation with 3 different IOLs (Collamer, SI40NB, AR40). Summary of data found in all patients. Data on file at STAAR Surgical Company.

7. Hoffman R. "The wonderful world of Collamer and the science behind the material" AAO Educational meeting, November 13, 2001. Data on file at STAAR Surgical AG.

8. Data on file at STAAR Surgical AG.

9. Data on file. STAAR Surgical, Monrovia, California

10. Huang IP, Clinch TE, Moshafar M, et al. Decentration of 3-Piece vs Plate Haptic Silicone Intraocular Lenses. J Cataract Refract Surg 1998;24:1505-1508.

11. Martin RG, Sanders DR. A comparison of higher order aberrations following implantation of four foldable intraocular lens designs. J Refract Surg. 2005;21:716-721.

12. Chang DF. Early rotational stability of the longer Staar toric intraocular lens: fifty consecutive cases. J Cataract Refract Surg. 2003;29:935-939.

13. Gontijo I, The Collamer Story. 2006. Data on file. STAAR Surgical, Monrovia, Calfornia.

14. Fry LL. Incidence of Glistenings in AcrySof IOLs. Presented at: American Society of Cataract and Refractive Surgery (ASCRS); April 3-8, 2009; San Francisco, Ca.

15. Apple DJ. Clinicopathological Study of the Importance Glistenings That Accumulate in the Optic of the AcrySof IOL. Presented at: American Society of Cataract and Refractive Surgery (ASCRS); April 3-8, 2009; San Francisco, Ca.

16. Lindstrom RL, Hoffman J, eds. Current acrylic lens choices: Review of materials, design and clinical observations. Ocular Surg News. 2000 (suppl).

17. Tester R, Pace Nl, Samore M, et al. Dysphotopsia in phakic and pseudophakic patients: Incidence in relation to intraocular lens type. J Cataract Refract Surg. 2000;26:810-816.

18. Toselli P, Mogayzel PJ, Faris B, et al. Mammalian cell growth on collagen-hydrogels. Scanning Electron Microscopy. 1984;3:1301-1312.

19. Izak AM, Werner L, Pandey ASK, Apple DJ. Calcification of modern foldable hydrogel intraocular lens designs. Eye, 2003 Apr; 17(3):393-406

20. Olson, R. Comparative Assessment of Intraocular Lens Calcification in an Animal Model. Presented at the XXIII Congress of the European Society of Cataract and Refractive Surgery (ESCRS): Lisbon.

21. Mak ST, Wong AC, Tsui WM. Calcification of a hydrophilic acrylic intraocular lens: Clinicopathological report. J Cataract Refract Surg. 2008 Dec; 34(12):2166-9.

References

1. Spherical aberrations by lens model: data on file, STAAR Surgical Company.